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Long-term gender-affirming hormone therapy appears to have minimal effect on cognitive function in older transgender women.

https://www.jsm.jsexmed.org/article/S1743-6095(21)00519-1/fulltext?fbclid=IwAR1DWUxwgf-thI4YTM-tDP92PKrGJArsT8OmeFI67U3QUd8k80xSTDKdT1E